doi: 10.1099/00221287-90-2-265.
Manganese mutagenesis in yeast. A practical application of manganese for the induction of mitochondrial antibiotic-resistant mutations
- PMID: 464
- DOI: 10.1099/00221287-90-2-265
Item in Clipboard
Manganese mutagenesis in yeast. A practical application of manganese for the induction of mitochondrial antibiotic-resistant mutations
J Gen Microbiol.
1975 Oct.
Abstract
When yeast cells were incubated for 4 to 8 h in yeast extract-peptone-glucose medium, pH 6, containing 8 mM-manganese, and then plated on selective media, there was a strong induction of antibiotic-resistant mutations. Indirect evidence suggests that practically all resistant mutants selected were of independent origin. The analysis of manganese-induced resistant mutants showed that most were extranuclear, while those tested showed recombination with known mitochondrial markers. Our results suggest that manganese can be considered as a mutagen which specifically induces mitochondrial mutations in Saccharomyces cerevisiae.
Similar articles
-
Induction by manganese of mitochondrial antibiotic resistance mutations in yeast.Mol Gen Genet. 1973 Nov 22;126(4):357-66. doi: 10.1007/BF00269445. Mol Gen Genet. 1973. PMID: 4593998 No abstract available.
-
Manganese mutagenesis in yeast. IV. The effects of magnesium, protein synthesis inhibitors and hydroxyurea on AntR induction in mitochondrial DNA.Mol Gen Genet. 1975 Oct 22;140(4):339-47. Mol Gen Genet. 1975. PMID: 1107804
-
Manganese mutagenesis in yeast. VI. Mn2+ uptake, mitDNA replication and ER induction: comparison with other divalent cations.Mol Gen Genet. 1977 Feb 28;151(1):69-76. doi: 10.1007/BF00446914. Mol Gen Genet. 1977. PMID: 325369
-
Cytoplasmic inheritance and mitochondrial genetics in yeasts.Methods Cell Biol. 1975;12:353-72. doi: 10.1016/s0091-679x(08)60964-4. Methods Cell Biol. 1975. PMID: 1105071 Review. No abstract available.
-
Genetic analysis of the chloroplast and mitochondrial genomes.Annu Rev Genet. 1974;8:347-91. doi: 10.1146/annurev.ge.08.120174.002023. Annu Rev Genet. 1974. PMID: 4613261 Review. No abstract available.
Cited by
-
Yeast as a Tool for Deeper Understanding of Human Manganese-Related Diseases.Genes (Basel). 2019 Jul 17;10(7):545. doi: 10.3390/genes10070545. Genes (Basel). 2019. PMID: 31319631 Free PMC article. Review.
-
Human Mitochondrial DNA Polymerase Metal Dependent UV Lesion Bypassing Ability.Front Mol Biosci. 2022 Mar 9;9:808036. doi: 10.3389/fmolb.2022.808036. eCollection 2022. Front Mol Biosci. 2022. PMID: 35355510 Free PMC article.
-
The strictly aerobic yeast Yarrowia lipolytica tolerates loss of a mitochondrial DNA-packaging protein.Eukaryot Cell. 2014 Sep;13(9):1143-57. doi: 10.1128/EC.00092-14. Epub 2014 Jun 27. Eukaryot Cell. 2014. PMID: 24972935 Free PMC article.
-
Characterization of the mechanism of action of the fungicide fenpicoxamid and its metabolite UK-2A.Pest Manag Sci. 2018 Feb;74(2):489-498. doi: 10.1002/ps.4743. Epub 2017 Nov 14. Pest Manag Sci. 2018. PMID: 28960782 Free PMC article.
-
Manganese-Induced Neurotoxicity through Impairment of Cross-Talk Pathways in Human Neuroblastoma Cell Line SH-SY5Y Differentiated with Retinoic Acid.Toxics. 2021 Dec 9;9(12):348. doi: 10.3390/toxics9120348. Toxics. 2021. PMID: 34941782 Free PMC article.