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. 1972 Nov;72(3):545-9.
doi: 10.1093/genetics/72.3.545.

Chemical selection of alcohol dehydrogenase negative mutants in drosophila

W H Sofer, M A Hatkoff

Chemical selection of alcohol dehydrogenase negative mutants in drosophila

W H Sofer et al. Genetics. 1972 Nov.

Abstract

We describe a selection procedure which utilizes the vapor from an unsaturated alcohol, 1-pentene-3-ol, for the detection and isolation of mutant flies with little or no alcohol dehydrogenase activity. ADH-negative flies are unaffected by exposure to the unsaturated alcohol, but ADH positives (wild-types) die after short exposure. The technique can be used to select rare ADH-negative individuals from large populations of wild-type flies.

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References

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