doi: 10.1007/BF00407888.
Effects of glucocorticosteroids on cultured human skin fibroblasts. III. Transient inhibition of cell proliferation in the early growth stages and reduced susceptibility in later growth stages
- PMID: 464664
- DOI: 10.1007/BF00407888
Item in Clipboard
Effects of glucocorticosteroids on cultured human skin fibroblasts. III. Transient inhibition of cell proliferation in the early growth stages and reduced susceptibility in later growth stages
Arch Dermatol Res.
.
Abstract
An immediate depression of the rate of cell proliferation occurred upon addition of glucocorticosteroids to cultures of human skin fibroblasts in the early growth stages. A reduced sensitivity or even insensitivity of the fibroblasts to growth inhibition inhibition was found upon the addition of the steroids at later stages of cell growth, when the cell density has increased. The inhibition in the early growth stages is transient and is most pronounced if the cultured medium is not renewed. This transient inhibition is not due to the development of steroid-resistant cell lines, and resembles the effect called tachyphylaxis, as is also observed in vasoconstriction tests.
Similar articles
-
Effects of corticosteroids on the growth and metabolism of fibroblasts cultured from human skin.Br J Dermatol. 1978 Sep;99(3):253-61. doi: 10.1111/j.1365-2133.1978.tb01994.x. Br J Dermatol. 1978. PMID: 81679
-
Effects of glucocorticosteroids on primary human skin fibroblasts. II. Effects on total protein and collagen biosynthesis by confluent cell cultures.Arch Dermatol Res (1975). 1977 Aug 22;259(2):125-34. doi: 10.1007/BF00557952. Arch Dermatol Res (1975). 1977. PMID: 907362
-
Effects of glucocorticosteroids on primary human skin fibroblasts. I. Inhibition of the proliferation of cultured primary human skin and mouse L929 fibroblasts.Arch Dermatol Res (1975). 1977 Aug 22;259(2):117-23. doi: 10.1007/BF00557951. Arch Dermatol Res (1975). 1977. PMID: 907361
-
Effects of glucocorticoids on cultured skin fibroblasts and keratinocytes.Int J Dermatol. 1984 Jan-Feb;23(1):11-24. doi: 10.1111/j.1365-4362.1984.tb05657.x. Int J Dermatol. 1984. PMID: 6202651 Review. No abstract available.
-
Factors involved in the control of fibroblast proliferation by glucocorticoids: a review.Endocr Rev. 1986 Aug;7(3):254-69. doi: 10.1210/edrv-7-3-254. Endocr Rev. 1986. PMID: 2427332 Review. No abstract available.
Cited by
-
Activation of anchorage-independent growth of HT1080 human fibrosarcoma cells by dexamethasone.In Vitro Cell Dev Biol Anim. 2002 Feb;38(2):111-7. doi: 10.1290/1071-2690(2002)038<0111:AOAIGO>2.0.CO;2. In Vitro Cell Dev Biol Anim. 2002. PMID: 11928993
-
Test systems for the determination of glucocorticoid receptor ligand induced skin atrophy.Dermatoendocrinol. 2011 Jul;3(3):175-9. doi: 10.4161/derm.3.3.15065. Epub 2011 Jul 1. Dermatoendocrinol. 2011. PMID: 22110776 Free PMC article.
-
Effects of glucocorticosteroids on cultured human skin fibroblasts. V. Influence of anabolic steroids on the inhibitory effects of clobetasol-17-propionate on cell proliferation and collagen synthesis.Arch Dermatol Res. 1979 Aug;266(1):75-82. doi: 10.1007/BF00412864. Arch Dermatol Res. 1979. PMID: 507931
-
Comparison of the Effectiveness of Onion Extract, Topical Steroid, and Petrolatum Emollient in Cosmetic Appearance of Upper Blepharoplasty Scar.J Curr Ophthalmol. 2020 Dec 12;32(4):408-413. doi: 10.4103/JOCO.JOCO_39_20. eCollection 2020 Oct-Dec. J Curr Ophthalmol. 2020. PMID: 33553845 Free PMC article.