Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1972 Dec;23(6):861-70.

Antibodies in delayed hypersensitive rats specifically desensitized by an intravenous injection of various antigen doses

L Jokipii, A M Jokipii

Antibodies in delayed hypersensitive rats specifically desensitized by an intravenous injection of various antigen doses

L Jokipii et al. Immunology. 1972 Dec.

Abstract

Rats with delayed hypersensitivity to bovine serum albumin (BSA) and diphtheria toxoid were specifically desensitized by an intravenous injection of BSA. The degree of desensitization was positively related to the dose of antigen. The 4-hour skin reactions to BSA were weaker, and the passive haemagglutinin titres, antigen-binding capacity and average avidity of the antibodies were lower in the desensitized rats than in controls. The suppression of delayed hypersensitivity was apparently not caused by increased circulating antibody activity, but by a cellular defect or a humoral blocking factor.

PubMed Disclaimer

References

    1. J Immunol. 1966 Jun;96(6):953-9 - PubMed
    1. Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1167-71 - PubMed
    1. Int Arch Allergy Appl Immunol. 1966;30(3):217-30 - PubMed
    1. Br Med Bull. 1967 Jan;23(1):24-9 - PubMed
    1. Immunology. 1968 Aug;15(2):159-71 - PubMed

LinkOut - more resources