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. 1979 May;36(2):153-6.
doi: 10.1136/oem.36.2.153.

Effects of tricresylphosphate on esterase activity of rat serum and tissues

M Manno, F Rigoni, G B Bartolucci, M Bianchi, M Mazzotta

Effects of tricresylphosphate on esterase activity of rat serum and tissues

M Manno et al. Br J Ind Med. 1979 May.

Abstract

The effect of tricresylphosphate (TCP) was studied in vitro and in vivo on the rat liver and brain enzymes acetylcholinesterase (ACC), butyrylcholinesterase (CHE), arylesterase (ARE), aliesterase (ALI), and the microsomal nicotinamide-adenine dinucleotide phosphate oxidase (NADPH2-oxidase) system. The results show that, in the male rat, TCP given intraperitoneally induces an increase in liver microsomal ARE AND NADPH2-oxidase and a decrease in ALI and cholinesterase; no activation of ARE and NADPH2-oxidase is observed in female rats.

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