Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1972 Dec;46(4):658-75.
doi: 10.1111/j.1476-5381.1972.tb06891.x.

Output of prostaglandins from the rabbit kidney, its increase on renal nerve stimulation and its inhibition by indomethacin

H A Davis, E W Horton

Output of prostaglandins from the rabbit kidney, its increase on renal nerve stimulation and its inhibition by indomethacin

H A Davis et al. Br J Pharmacol. 1972 Dec.

Abstract

1. In each of six experiments, prostaglandins were identified in the renal venous blood of the rabbit. The concentrations in renal venous blood were up to 45 times higher than in aortic blood, suggesting that most of the prostaglandins originate from the kidney.2. Prostaglandins E(2), F(2a) and a prostaglandin of the A, C or B series were estimated by biological assay after solvent partition and column or thin-layer chromatography.3. Prostaglandins E(2) and F(2a) were identified conclusively by combined gas chromatography-mass spectrometry.4. Electrical stimulation of the renal nerve increased the output of prostaglandins.5. Indomethacin (10 mg/kg) injected intravenously, reduced the output of prostaglandins into renal venous blood and prevented the increase in output on renal nerve stimulation.

PubMed Disclaimer

References

    1. Br J Pharmacol. 1969 Nov;37(3):705-22 - PubMed
    1. J Biol Chem. 1971 Nov;246(21):6700-2 - PubMed
    1. Ann N Y Acad Sci. 1971 Apr 30;180:410-5 - PubMed
    1. Nat New Biol. 1971 Jun 23;231(25):235-7 - PubMed
    1. Nature. 1970 Sep 19;227(5264):1255-7 - PubMed

LinkOut - more resources