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. 1972 Jan;5(1):127-31.
doi: 10.1128/iai.5.1.127-131.1972.

Mycoplasmacidal activity of peroxidase-H2O2-halide systems

A A Jacobs, I E Low, B B Paul, R R Strauss, A J Sbarra

Mycoplasmacidal activity of peroxidase-H2O2-halide systems

A A Jacobs et al. Infect Immun. 1972 Jan.

Abstract

A mycoplasmacidal system consisting of myeloperoxidase (MPO)-containing granules, H(2)O(2), and a halide is described. In all parameters measured, it appears to be identical to the MPO-H(2)O(2)-halide bactericidal system previously reported. It has a pH optimum of approximately 5.5 and an optimal MPO:H(2)O(2) ratio of 1:25. The halide requirement can be satisfied by either chloride or iodide. Through the use of taurine or horseradish peroxidase substitution, chloride-mediated killing can be distinguished from iodide-mediated killing. The relationship of this mycoplasmacidal system to other mycoplasmacidal systems and to host surveillance of mycoplasma is discussed.

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