Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Jul;39(1):39-45.
doi: 10.1007/BF01008073.

Remission induction and remission maintenance in adult acute nonlymphocytic leukemia employing a modified cytostatic (COAP) regimen

D Gerecke, W D Hirschmann, R Voigtmann, R Gross

Remission induction and remission maintenance in adult acute nonlymphocytic leukemia employing a modified cytostatic (COAP) regimen

D Gerecke et al. Blut. 1979 Jul.

Abstract

Thirty adult patients suffering from acute nonlymphocytic leukemia (ANLL) were treated according to a modified COAP regimen. Vincristine, cyclophosphamide, and prednisone were given by push injection, while cytosine arabinoside was infused over periods of 8 h. Nineteen patients (63%) achieved complete remission. Remission maintenance therapy consisted of 6-mercaptopurine daily and methotrexate twice weekly. Later in the study, COAP consolidation and reinduction was added, which improved the median duration of complete remission from 7 to 24 months. Comparison of the results with the literature shows that the modified COAP regimen is one of the most effective treatment schedules for adult ANLL.

PubMed Disclaimer

References

    1. Lancet. 1977 Mar 5;1(8010):497-9 - PubMed
    1. Br J Cancer. 1973 Nov;28(5):365-76 - PubMed
    1. Cancer. 1976 Feb;37(2):653-9 - PubMed
    1. Blut. 1978 Jun 20;36(6):372-6 - PubMed
    1. Med Welt. 1975 Sep 26;26(39):1783-5 - PubMed