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Comparative Study
. 1972 Dec;2(6):464-9.
doi: 10.1128/AAC.2.6.464.

Biological activity of Sch 14342, an aminoglycoside antibiotic coproduced in the gentamicin fermentation

J A Waitz, E L Moss Jr, E M Oden, G H Wagman, M J Weinstein
Comparative Study

Biological activity of Sch 14342, an aminoglycoside antibiotic coproduced in the gentamicin fermentation

J A Waitz et al. Antimicrob Agents Chemother. 1972 Dec.

Abstract

Sch 14342 is an aminoglycoside antibiotic coproduced as a minor component in the gentamicin fermentation. Sch 14342 was found to have the same antibacterial spectrum as gentamicin in vitro and in vivo, and was approximately one-third as active in mouse protection tests. Sch 14342 relative to gentamicin was one-third as toxic in acute tests in mice, one-eighth as toxic in renal toxicity tests in dogs, and an estimated one-tenth as toxic in cat ataxia tests. Sch 14342 possesses a significantly improved therapeutic index relative to gentamicin with reference to ataxia potential and renal toxicity.

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References

    1. J Infect Dis. 1969 Apr-May;119(4):355-60 - PubMed
    1. J Antibiot (Tokyo). 1970 Nov;23(11):559-65 - PubMed
    1. J Chromatogr. 1972 Jul 26;70(1):171-3 - PubMed

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