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Comparative Study
. 1972 Dec;2(6):485-91.
doi: 10.1128/AAC.2.6.485.

Inhibition of peptidoglycan synthesis by the antibiotic diumycin A

E J Lugtenberg, J A Hellings, G J van de Berg
Comparative Study

Inhibition of peptidoglycan synthesis by the antibiotic diumycin A

E J Lugtenberg et al. Antimicrob Agents Chemother. 1972 Dec.

Abstract

Diumycin A, a new antibiotic, was found to inhibit cell wall synthesis by Staphylococcus aureus, a phenomenon accompanied by accumulation of uridine-5'-diphosphate-N-acetyl-muramyl-pentapeptide. The antibiotic inhibited in vitro peptidoglycan synthesis by particulate preparations of Bacillus stearothermophilus and Escherichia coli by preventing the utilization of N-acetyl-glucosamine-N-acetyl-muramyl-pentapeptide. In contrast to vancomycin, the antibiotics diumycin, prasinomycin, moenomycin, 11.837 RP, and enduracidin do not inhibit particulate d-alanine carboxypeptidase.

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References

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