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. 1972 Oct 6;178(4056):75-7.
doi: 10.1126/science.178.4056.75.

6-Hydroxydopa depletion of brain norepinephrine and the function of aggressive behavior

N B Thoa, B Eichelman, J S Richardson, D Jacobowitz

6-Hydroxydopa depletion of brain norepinephrine and the function of aggressive behavior

N B Thoa et al. Science. .

Abstract

A significant increase in shock-induced aggression occurs in the rat 4 days after an intraventricular injection of 90 micrograms of 6-hydroxydopa. Both fluorescent histology and biochemical assay demonstrate that brain norepinephrine is reduced by 90 micrograms of 6-hydroxydopa, while brain dopamine remains unaltered. This suggests that one form of aggressive behavior (shock-induced aggression) is modulated through a central noradrenergic system.

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