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. 1979 May;20(5):394-9.
doi: 10.1136/gut.20.5.394.

Endogenous prostaglandins in peptic ulcer disease

R Baker, B M Jaffe, C W Venables

Endogenous prostaglandins in peptic ulcer disease

R Baker et al. Gut. 1979 May.

Abstract

Plasma concentrations of prostaglandins E and F have been measured by radioimmunoassay in patients undergoing diagnostic upper intestinal endoscopy. The results fail to support a previously reported deficiency of plasma PGE in duodenal ulcer patients. Plasma prostaglandin concentrations failed to correlate with the parameters of gastric secretion studied; and were unaffected by histamine H2-receptor blockade or the activity of duodenal ulceration. During combined pentagastrin and insulin secretory studies there was a significant correlation between the outputs of PGE and acid into gastric juice.

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