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. 1973 Jan 5;179(4068):77-9.
doi: 10.1126/science.179.4068.77.

Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone

P Brazeau, W Vale, R Burgus, N Ling, M Butcher, J Rivier, R Guillemin

Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone

P Brazeau et al. Science. .

Abstract

A peptide has been isolated from ovine hypothalamus which, at 1 x 10(-9)M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH The synthetic replicate is biologically active.

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