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. 1973 Jan 5;179(4068):86-8.
doi: 10.1126/science.179.4068.86.

Photoreactivation of ultraviolet-induced chromosomal aberrations

H G Griggs, M A Bender

Photoreactivation of ultraviolet-induced chromosomal aberrations

H G Griggs et al. Science. .

Abstract

Ultraviolet induces only chromatid-type aberrations in synchronized G(1) V-79 Chinese hamster and A8W243 Xenopus tissue culture cells. Posttreatment with white light prevents expression of most potential aberrations in the A8 toad cell, which possesses a photoreactivation enzyme. We conclude that the major ultraviolet-induced DNA lesion leading to chromosomal aberrations is the pyrimidine dimer.

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