Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1979 Jun 19;49(2):185-9.
doi: 10.1007/BF00277641.

Quantitative studies on the arrangement of human metaphase chromosomes. VI. The association pattern of acrocentric chromosomes in patients with trisomy 13

H Zankl, D Michaelsen, K D Zang
Comparative Study

Quantitative studies on the arrangement of human metaphase chromosomes. VI. The association pattern of acrocentric chromosomes in patients with trisomy 13

H Zankl et al. Hum Genet. .

Abstract

The association pattern was studied in 1182 mitoses of 21 patients with trisomy 13 and in a control group. In addition, 173 trisomic mitoses were compared with the same number of diploid mitoses in a case of mosaicism. The number of mitoses with associations was no higher in the trisomic cells than in cells with normal karyotypes. Some differences were observed in the frequency of associations per cell and of the types of associations in the patient group and in the trisomic cells of the mosaic case. The number of associations in which more than two acrocentric chromosomes were involved was unexpectedly low in the cells with a supernumerary chromosome 13. The results are interpreted as suggesting the existence of a compensatory mechanism activated by the additional acrocentric chromosome.

PubMed Disclaimer

References

    1. Cytogenet Cell Genet. 1977;19(4):185-96 - PubMed
    1. Humangenetik. 1974 Apr 24;22(1):17-22 - PubMed
    1. Cytogenetics. 1968;7(6):455-70 - PubMed
    1. Humangenetik. 1969;7(1):9-21 - PubMed
    1. Humangenetik. 1975 Oct 7;29(4):265-70 - PubMed

Publication types