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. 1973 Feb 16;179(4074):691-3.
doi: 10.1126/science.179.4074.691.

Association of the HL-A7 cross-reacting group with a specific reaginic antibody response in allergic man

D G Marsh, W B Bias, S H Hsu, L Goodfriend

Association of the HL-A7 cross-reacting group with a specific reaginic antibody response in allergic man

D G Marsh et al. Science. .

Abstract

A relatively small proportion (17 percent) of individuals highly allergic to ragweed were found to develop marked reaginic (immunoglobulin E-mediated) skin sensitivity to a minor ragweed pollen allergen Ra5 (molecular weight 5200). Sensitivity to Ra5 was significantly associated with the possession of a major histocompatibility antigen of the HL-A7 cross-reacting group. This appears to be the first evidence of a strong association between a specific immune response and a specific group of closely related HL-A antigens in man.

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