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Comparative Study
. 1973 Feb 9;179(4073):584-5.
doi: 10.1126/science.179.4073.584.

Amphotericin B methyl ester hydrochloride and amphotericin B: comparative acute toxicity

G R Keim Jr, J W Poutsiaka, J Kirpan, C H Keysser
Comparative Study

Amphotericin B methyl ester hydrochloride and amphotericin B: comparative acute toxicity

G R Keim Jr et al. Science. .

Abstract

In single-dose parenteral studies with mice and dogs, the methyl ester hydrochloride of amphotericin B proved to be significantly less toxic than the parent compound, especially to the kidney.

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