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. 1973 Mar 2;179(4076):916-8.
doi: 10.1126/science.179.4076.916.

Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia

R J Wyatt, D L Murphy, R Belmaker, S Cohen, C H Donnelly, W Pollin

Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia

R J Wyatt et al. Science. .

Abstract

Monoamine oxidase activity in blood platelets was measured, with [(14)C]tryptamine as substrate, in 13 monozygotic twin pairs discordant for schizophrenia and in 23 normal volunteers. The monoamine oxidase activity of both schizophrenic and nonschizophrenic co-twins was significantly lower than it was for the normals, and it was highly correlated between twins. In addition, there was a significant inverse correlation between a measure of the degree of the schizophrenic disorder and the monoamine oxidase activity. These data suggest, but do not prove, that reduced platelet monoamine oxidase activity may provide a genetic marker for vulnerability to schizophrenia.

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