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. 1979 Sep;64(3):866-9.
doi: 10.1172/JCI109535.

Deletion of the A gamma-globin gene in G gamma-delta beta-thalassemia

S H Orkin, B P Alter, C Altay

Deletion of the A gamma-globin gene in G gamma-delta beta-thalassemia

S H Orkin et al. J Clin Invest. 1979 Sep.

Abstract

In an individual homozygous for G gamma-delta beta-thalassemia, a physical alteration in gamma-globin gene organization was detected by restriction enzyme mapping. The data indicated that the absence of A gamma-globin chains resulted from extension of the DNA deletion from the delta beta-globin gene region into the gamma-globin gene region rather than a functional disturbance of gamma-gene expression.

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References

    1. Nature. 1979 Mar 15;278(5701):227-31 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Dec;75(12):5950-4 - PubMed
    1. Nucleic Acids Res. 1979 Jun 11;6(7):2519-44 - PubMed
    1. Nature. 1979 Jun 14;279(5714):598-603 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1222-6 - PubMed

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