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Case Reports
. 1979 Jun;16(3):225-6.
doi: 10.1136/jmg.16.3.225.

Additional pedigree supporting the frequent origin of XXYY from consecutive meiotic non-disjunction in paternal gametogenesis

A Rinaldi, N Archidiacono, M Rocchi, G Filippi
Case Reports

Additional pedigree supporting the frequent origin of XXYY from consecutive meiotic non-disjunction in paternal gametogenesis

A Rinaldi et al. J Med Genet. 1979 Jun.

Abstract

A 48,XXYY Sardinian patient, born to a 46,XX mother heterozygous for the Gd Mediterranean mutant, and to a 46,XY father hemizygous for the same mutant, was found to have a mosaic distribution of G6PD(+) and G6PD(-) peripheral red blood cells. The most likely interpretation of this finding is that the propositus is an additional example of an XXYY zygote derived from a consecutive meiotic non-disjunction during paternal gametogenesis.

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References

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    1. Am J Hum Genet. 1976 Sep;28(5):496-505 - PubMed
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