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. 1973 Feb 2;179(4072):490-2.
doi: 10.1126/science.179.4072.490.

Lack of tolerance to 9 -tetrahydrocannabinol in chimpanzees

D P Ferraro, D M Grilly

Lack of tolerance to 9 -tetrahydrocannabinol in chimpanzees

D P Ferraro et al. Science. .

Abstract

Five chimpanzees were given Delta(9)-tetrahydrocannabinol (Delta(9)THC): 1.0 milligram per kilogram of body weight for 21 days and 4.0 milligrams per kilogram of body weight for 42 days. Although accuracy and speed of performance on a delayed matching-to-sample task were significantly affected by both doses, tolerance to Delta(9)THC did not develop. No long-term behavioral effects of Delta(9)THC were observed after termination of the drug regimens.

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