Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 Jan 20;1(5846):143-6.
doi: 10.1136/bmj.1.5846.143.

Effect of orally administered prostaglandin E 2 and its 15-methyl analogues on gastric secretion

S M Karim, D C Carter, D Bhana, P A Ganesan

Effect of orally administered prostaglandin E 2 and its 15-methyl analogues on gastric secretion

S M Karim et al. Br Med J. .

Abstract

The effect of orally administered prostaglandin E(2) and its synthetic 15-methyl analogues on gastric secretion in man was studied. The parent E(2) compound did not inhibit basal secretion, whereas both the 15 (S) 15-methyl-E(2) methyl ester and its isomer, 15 (R) 15-methyl-E(2) methyl ester inhibited basal acid secretion. This action is likely to be a direct one on the parietal cell, and it could prove of value in the treatment of peptic ulcer.

PubMed Disclaimer

References

    1. J Am Chem Soc. 1972 May 17;94(10):3651-2 - PubMed
    1. J Obstet Gynaecol Br Commonw. 1972 Aug;79(8):737-43 - PubMed
    1. Prostaglandins. 1972 Apr;1(4):319-25 - PubMed
    1. J Physiol. 1968 Mar;195(2):34P-36P - PubMed
    1. Gastroenterology. 1968 Oct;55(4):481-7 - PubMed

LinkOut - more resources