doi: 10.1136/bmj.1.5846.143.
Effect of orally administered prostaglandin E 2 and its 15-methyl analogues on gastric secretion
- PMID: 4706806
- PMCID: PMC1588413
- DOI: 10.1136/bmj.1.5846.143
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Effect of orally administered prostaglandin E 2 and its 15-methyl analogues on gastric secretion
Br Med J.
.
Abstract
The effect of orally administered prostaglandin E(2) and its synthetic 15-methyl analogues on gastric secretion in man was studied. The parent E(2) compound did not inhibit basal secretion, whereas both the 15 (S) 15-methyl-E(2) methyl ester and its isomer, 15 (R) 15-methyl-E(2) methyl ester inhibited basal acid secretion. This action is likely to be a direct one on the parietal cell, and it could prove of value in the treatment of peptic ulcer.
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