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Clinical Trial
. 1975 Mar 22;1(7908):660-2.
doi: 10.1016/s0140-6736(75)91761-4.

Immunogenicity and acceptability of a human diploid-cell culture rabies vaccine in volunteers

Clinical Trial

Immunogenicity and acceptability of a human diploid-cell culture rabies vaccine in volunteers

F Y Aoki et al. Lancet. .

Abstract

A rabies vaccine, prepared in human diploid-cell culture, was given intradermally (i.d.) or intramuscularly (i.m.) to 35 volumteers who had not previously received prophylactic immunisation. Rabies neutralising antibody titres rose sharply after the first dose, and 4 weeks after the second dose all titres were above 1/80 (1-7 i.u. per ml.). Immunisation via the i.d. and i.m. routes was equally successful in terms of likely immune status, but the i.d. rate was associated with many more local sideeffects.

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