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. 1979 Aug 30;280(5725):815-9.
doi: 10.1038/280815a0.

Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen

P Valenzuela, P Gray, M Quiroga, J Zaldivar, H M Goodman, W J Rutter

Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen

P Valenzuela et al. Nature. .

Abstract

DNA extracted from hepatitis B virus Dane particles has been cloned in bacteria using a plasmid vector. A full-length clone has been examined by restriction endonuclease analysis, and the nucleotide sequence of an 892-base pair fragment from cloned hepatitis B viral DNA encoding the surface antigen gene is reported. The amino acid sequence deduced from the DNA indicates that the surface antigens is a protein consisting of 226 amino acids and with a molecular weight of 25,398. The portion of the gene coding for this protein apparently contains no intervening sequences.

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