doi: 10.1159/000181635.
Renal tubular necrosis following cephalothin
- PMID: 471144
- DOI: 10.1159/000181635
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Renal tubular necrosis following cephalothin
Nephron.
1979.
Abstract
Renal tubular necrosis was observed following intramuscular injections of cephalothin into rats. Lesions were consistently produced with 5.0g/kg and were maximal in severity at the 2nd and 3rd days following injection. Renal tubular necrosis following cephalothin was similar in morphology to that produced by nephrotoxic doses (2.0 g/kg) of cephaloridine. The nephrotoxic potential of cephalothin has been demonstrated in the rat model and caution is urged in using large doses of cephalothin.
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