Role of delayed hypersensitivity in blastomycosis of mice
- PMID: 4713689
- PMCID: PMC422679
- DOI: 10.1128/iai.7.3.329-334.1973
Role of delayed hypersensitivity in blastomycosis of mice
Abstract
C57BL/6J mice rendered hypersensitive to Blastomyces dermatitidis were protected from the lethal effects of a blastomyces infection. This protection was observed following a lethal intraperitoneal challenge with viable cells 15 days after subcutaneous inoculation with 3.9 x 10(4) viable cells. Delayed hypersensitivity was induced in C57 mice by two injections of Merthiolate-killed cells in adjuvant or by a single injection of viable cells. Development of hypersensitivity was determined at appropriate intervals by footpad injection with killed yeast cells.
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