Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 Jan;47(1):138-40.
doi: 10.1111/j.1476-5381.1973.tb08167.x.

Cellular and metabolic tolerance to an opioid narcotic in mouse brain

A Goldstein, B A Judson, P Sheehan

Cellular and metabolic tolerance to an opioid narcotic in mouse brain

A Goldstein et al. Br J Pharmacol. 1973 Jan.

Abstract

1. Running activity and brain levorphanol concentration were measured in nontolerant and tolerant mice given various doses of (3)H-levorphanol.2. The principal factor responsible for tolerance in the mouse is a loss of sensitivity to the narcotic drug at the cellular level in brain; despite adequate brain concentrations, the pharmacological effects are diminished or absent.3. There is also metabolic tolerance; a given dose establishes a lower brain concentration in tolerant than in non-tolerant animals.4. The two kinds of tolerance are distinguished here and the contribution of each is assessed.

PubMed Disclaimer

References

    1. J Pharmacol Exp Ther. 1967 Aug;157(2):459-71 - PubMed
    1. J Pharmacol Exp Ther. 1962 May;136:232-41 - PubMed
    1. Proc Natl Acad Sci U S A. 1970 Jul;66(3):944-51 - PubMed
    1. J Pharmacol Exp Ther. 1969 Oct;169(2):175-84 - PubMed

LinkOut - more resources