doi: 10.1126/science.181.4098.458.
Infertility in female rabbits immunized with lactate dehydrogenase X
- PMID: 4718114
- DOI: 10.1126/science.181.4098.458
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Infertility in female rabbits immunized with lactate dehydrogenase X
Science.
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Abstract
Immunization of female rabbits with the sperm-specific lactate dehydrogenase (LDH-X) resulted in a highly significant reduction of pregnancies compared to nonimmunized controls. This is the first demonstration of immunosuppression of fertility by a crystalline protein shown to be strictly homogeneous by ultracentrifugation, polyacrylamide gel electrophoresis, immunodiffusion, and micro complement fixation.
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