Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 Jun;26(6):393-5.
doi: 10.1136/jcp.26.6.393.

Bactericidal activity of metronidazole against Bacteroides fragilis

J P Whelan, J H Hale

Bactericidal activity of metronidazole against Bacteroides fragilis

J P Whelan et al. J Clin Pathol. 1973 Jun.

Abstract

Metronidazole was found to be active against Bacteroides fragilis strains isolated from human lesions. The minimal inhibitory concentrations (MIC) were from 0.16 to 2.5 mug/ml and the minimal bactericidal concentrations (MBC) were from 0.16 to 2.5 mug/ml; usually the MIC and MBC figures were equivalent. These levels are easily attainable in the serum following normal therapeutic doses. The drug is not toxic and side effects are rare and it would therefore seem highly suitable for treating Bacteroides infections and also may be considered prophylactically in certain situations that are described.

PubMed Disclaimer

References

    1. Zentralbl Bakteriol Orig. 1970;213(2):258-62 - PubMed
    1. Surg Clin North Am. 1968 Aug;48(4):787-98 - PubMed
    1. Lancet. 1971 Oct 30;2(7731):982-3 - PubMed
    1. Ann Intern Med. 1968 Feb;68(2):308-17 - PubMed
    1. J Clin Pathol. 1954 Feb;7(1):37-44 - PubMed

LinkOut - more resources