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. 1973 Aug 24;181(4101):751-2.
doi: 10.1126/science.181.4101.751.

Differences in collagen metabolism between normal and osteoarthritic human articular cartilage

Differences in collagen metabolism between normal and osteoarthritic human articular cartilage

M Nimni et al. Science. .

Abstract

Normal human articular cartilage synthesizes only one type of a chain, which exhibits the chromatographic behavior of the alpha(l)(II) chains described for chick and bovine cartilage. Osteoarthritic cartilage, on the other hand, synthesizes in addition a collagen containing alpha(2) chains and beta components. The different structural features of the two types of collagen may account for some of the functional defects of osteoarthritic cartilage.

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