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. 1973 Aug;8(2):173-7.
doi: 10.1128/iai.8.2.173-177.1973.

Pyrogenicity and immunogenicity of lipid A complexed with bovine serum albumin or human serum albumin

E T Rietschel, Y B Kim, D W Watson, C Galanos, O Lüderitz, O Westphal

Pyrogenicity and immunogenicity of lipid A complexed with bovine serum albumin or human serum albumin

E T Rietschel et al. Infect Immun. 1973 Aug.

Abstract

The lipid A component of bacterial lipopolysaccharides (endotoxins), when complexed to bovine serum albumin (BSA) or human serum albumin (HSA), was shown to be a potent pyrogen. Furthermore, rabbits could be protected against endotoxin fever by immunization with both lipid A.BSA and lipid A.HSA complexes. The results presented in this paper show that lipid A is responsible for the pyrogenic activity of endotoxins and their ability to induce pyrogenic immunity.

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