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. 1979 Sep 28;205(4413):1412-4.
doi: 10.1126/science.472759.

Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils

J E Niedel, I Kahane, P Cuatrecasas

Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils

J E Niedel et al. Science. .

Abstract

Tetramethylrhodamine labeled N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys is a potent chemoattractant for human neutrophils. Binding of this peptide to living neutrophils was observed by means of video intensification microscopy. At 37 degrees C, diffuse membrane fluorescence was seen initially, followed by rapid aggregation and internalization of the fluorescent peptide. These processes are dependent on specific binding to the formal peptide chemotactic receptor.

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