Double-blind study of the analgesic effect of indoprofen (K 4277)
- PMID: 47280
- DOI: 10.1002/cpt1975173277
Double-blind study of the analgesic effect of indoprofen (K 4277)
Abstract
In a double-blind study, indoprofen was superior to placebo in decreasing pain in patients with primary and metastatic cancer and with neuralgia. A single oral dose of 200 mg was more active than a 100-mg dose. The preferences of patients proved to be a more sensitive parameter in this study than scores of pain intensity, pain relief, and other related measurements (SPID, TOTPAR, and Peak PID).
Similar articles
-
Indoprofen, a new analgesic and anti-inflammatory drug in cancer pain.Clin Pharmacol Ther. 1975 Mar;17(3):284-9. doi: 10.1002/cpt1975173284. Clin Pharmacol Ther. 1975. PMID: 47281 Clinical Trial.
-
Application of nonparametric procedure for bioassay data to the evaluation of analgesics in man.J Clin Pharmacol. 1977 Apr;17(4):177-84. doi: 10.1177/009127007701700401. J Clin Pharmacol. 1977. PMID: 321487 Clinical Trial.
-
A comparative oral analgesic study of indoprofen, aspirin, and placebo in postpartum pain.J Clin Pharmacol. 1985 Jul-Aug;25(5):374-80. doi: 10.1002/j.1552-4604.1985.tb02858.x. J Clin Pharmacol. 1985. PMID: 3897296 Clinical Trial.
-
Assessment of analgesic drugs.Pharmacol Ther. 1981;12(3):589-98. doi: 10.1016/0163-7258(81)90100-5. Pharmacol Ther. 1981. PMID: 7025034 Review. No abstract available.
-
Relieving pain using dose-extending placebos: a scoping review.Pain. 2016 Aug;157(8):1590-1598. doi: 10.1097/j.pain.0000000000000566. Pain. 2016. PMID: 27023425 Free PMC article.
Cited by
-
Nonsteroidal anti-inflammatory drugs and pain in cancer patients: a systematic review and reappraisal of the evidence.Br J Anaesth. 2019 Aug;123(2):e412-e423. doi: 10.1016/j.bja.2019.02.028. Epub 2019 May 20. Br J Anaesth. 2019. PMID: 31122736 Free PMC article.
-
Effect of analgesic agents on emptying of the gallbladder in man.Eur J Clin Pharmacol. 1976 Jun 15;10(2):127-31. doi: 10.1007/BF00609471. Eur J Clin Pharmacol. 1976. PMID: 786671 Clinical Trial.
-
Response of pathological ischaemic muscle pain to analgesics.Br J Clin Pharmacol. 1980 Feb;9(2):165-9. doi: 10.1111/j.1365-2125.1980.tb05828.x. Br J Clin Pharmacol. 1980. PMID: 7356905 Free PMC article. Clinical Trial.
-
Lumbar epidural morphine as an effective analgesic following cholecystectomy.Can Anaesth Soc J. 1981 Nov;28(6):523-9. doi: 10.1007/BF03007147. Can Anaesth Soc J. 1981. PMID: 7306855