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Comparative Study
. 1973 Apr;3(4):491-504.
doi: 10.1016/0090-6980(73)90157-3.

Induction of abortion by intra- and extra-amniotic prostaglandin F2 administration

P A Järvinen, S Pennanen, P Ylöstalo
Comparative Study

Induction of abortion by intra- and extra-amniotic prostaglandin F2 administration

P A Järvinen et al. Prostaglandins. 1973 Apr.

Abstract

PIP: PGF2 alpha was administered intrauterine in 115 patients during the 11th to 20th week of pregnancy for abortion induction. An intra-amniotic method was used in 61 cases, an extra-amniotic one in 54 cases. Average total dose administered was 35.1 (range 5 to 65 mg) in the amniotic group and 6358 mcg (range 1500 to 14000 mcg) in the extra-amniotic group. The intra-amniotic group had an abortion rate of 92% and a 74% rate of side effects, mainly gastrointestinal irritation. Corresponding figures for the extra-amniotic group were 72% and 54% respectively. In the extra-amniotic group, doses of 4750 mcg or more increased the abortion rate up to 80% and side effects up to 64%. There were no serious complications. The intra-amniotic approach of prostaglandin induction is suitable for second trimester therapeutic abortions. The extra-amniotic approach is useful in cases of fetus mortuus and hydatiform mole.

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