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. 1973 Sep 7;181(4103):954-5.
doi: 10.1126/science.181.4103.954.

Zinc: a trace element essential in vitamin A metabolism

J C Smith Jr, E G McDaniel, F F Fan, J A Halsted

Zinc: a trace element essential in vitamin A metabolism

J C Smith Jr et al. Science. .

Abstract

Zinc is necessary to maintain normal concentrations of vitamin A in plasma. By using animals deficient in both zinc and vitamin A, it was demonstrated that zinc is necessary for normal mobilization of vitamin A from the liver. These results suggest that cases of depressed vitamin A in plasma, unresponsive to vitamin A therapy, may respond to zinc supplementation.

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