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. 1973 Jun;48(2):194-7.
doi: 10.1111/j.1476-5381.1973.tb06905.x.

Actions of levodopa on the blood pressure of conscious rabbits

D B Calne, J L Reid

Actions of levodopa on the blood pressure of conscious rabbits

D B Calne et al. Br J Pharmacol. 1973 Jun.

Abstract

1. In conscious rabbits, the rapid intravenous injection of levodopa alone does not have any significant effects on the blood pressure in doses up to 10 mg/kg.2. After inhibition of monoamine oxidase, levodopa induces a sustained pressor response.3. This response can be blocked by inhibition of extracerebral decarboxylase.4. Possible mechanisms for these interactions are discussed, together with their therapeutic implications in Parkinsonism.

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