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. 1973 Jul 6;181(4094):76-8.
doi: 10.1126/science.181.4094.76.

Regulation of muscle acetylcholine sensitivity by muscle activity in cell culture

S A Cohen, G D Fischbach

Regulation of muscle acetylcholine sensitivity by muscle activity in cell culture

S A Cohen et al. Science. .

Abstract

Muscle in tissue culture provides a good system for studying longterm changes in surface membrane acetylcholine sensitivity. Muscle fibers stimulated intermittently over prolonged periods are less sensitive to iontophoretically applied acetylcholine and bind less (125)I-labeled alpha-bungarotoxin than inactive fibers.

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