[Induction of experimental allergic encephalomyelitis with encephalitogenic myelin proteins from the spinal cord of a bull]
[Article in
Russian]
- PMID: 473681
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[Induction of experimental allergic encephalomyelitis with encephalitogenic myelin proteins from the spinal cord of a bull]
[Article in
Russian]
Vopr Med Khim.
1979 Jul-Aug.
Abstract
A homogenous base protein, exhibiting high encephalitogenic activity towards guinea pigs and rabbits, was isolated from bovine spinal cord using column chromatography. Administration of the preparation obtained together with Freund's adjuvant into the animals caused development of neurogic symptoms typical for experimental allergic encephalomyelitis as well as formation of demyelinization foci both in spinal cord and in brain of guinea pigs and rabbits.
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