doi: 10.1084/jem.138.1.300.
Monoclonal production of both IgM and IgG1 antihapten antibody
- PMID: 4736831
- PMCID: PMC2180547
- DOI: 10.1084/jem.138.1.300
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Monoclonal production of both IgM and IgG1 antihapten antibody
J Exp Med.
.
Abstract
The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse micro-chain antibody and goat antimouse gamma1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 anti-DNP antibody (16% and 14%, respectively) was considerably higher than that which would be predicted by a random distribution. It would thus appear that IgM and IgG1 antibody can be made by the clonal progeny of a single precursor cell.
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