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. 1973 Jul 1;138(1):300-5.
doi: 10.1084/jem.138.1.300.

Monoclonal production of both IgM and IgG1 antihapten antibody

J L Press, N R Klinman

Monoclonal production of both IgM and IgG1 antihapten antibody

J L Press et al. J Exp Med. .

Abstract

The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse micro-chain antibody and goat antimouse gamma1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 anti-DNP antibody (16% and 14%, respectively) was considerably higher than that which would be predicted by a random distribution. It would thus appear that IgM and IgG1 antibody can be made by the clonal progeny of a single precursor cell.

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References

    1. Immunochemistry. 1969 May;6(3):451-9 - PubMed
    1. J Exp Med. 1964 Mar 1;119:485-502 - PubMed
    1. Proc Natl Acad Sci U S A. 1970 Jul;66(3):657-63 - PubMed
    1. Nature. 1970 Jul 25;227(5256):341-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1970 Jun;66(2):337-43 - PubMed