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. 1973 Oct 19;182(4109):293-5.
doi: 10.1126/science.182.4109.293.

Neuromuscular junction in myasthenia gravis: decreased acetylcholine receptors

D M Fambrough, D B Drachman, S Satyamurti

Neuromuscular junction in myasthenia gravis: decreased acetylcholine receptors

D M Fambrough et al. Science. .

Abstract

The number of acetylcholine receptors was determined in the neuromuscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of (125)1-labeled alpha-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.

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