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. 1979:117:95-110.
doi: 10.1007/978-1-4757-6589-2_5.

Estrogen control of progesterone receptor induction in human breast cancer: role of nuclear estrogen receptor

K B Horwitz, W L McGuire

Estrogen control of progesterone receptor induction in human breast cancer: role of nuclear estrogen receptor

K B Horwitz et al. Adv Exp Med Biol. 1979.

Abstract

We have provocative data which suggest that the nuclear estrogen-receptor complex interacts with DNA, that this interaction is required for appropriate receptor turnover or processing, and that processing may be essential for induction of a specific protein by estrogen. If the receptor is improperly inserted into DNA, as for instance when it is bound by nafoxidine, processing fails and the biological effect is blunted.

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