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. 1973 Nov;52(11):2848-52.
doi: 10.1172/JCI107480.

Abnormal bone mineral maturation in the chronic uremic state

J E Russell, J D Termine, L V Avioli

Abnormal bone mineral maturation in the chronic uremic state

J E Russell et al. J Clin Invest. 1973 Nov.

Abstract

X-ray diffraction analysis of bone from chronically uremic but nonacidotic rats with normocalcemia and hyperphosphatemia revealed smaller apatite crystals and an increase in the X-ray amorphous mineral fraction when compared to age-matched, pair-fed control animals, indicating less advanced mineral maturation in the uremic animals. Studies in animals with varied degrees of chronic renal insufficiency revealed a progression of the bone crystal maturational defect with advancing uremia.

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