doi: 10.1136/bmj.4.5889.382.
Use of 5-fluorocytosine in patients with impaired renal function
- PMID: 4749757
- PMCID: PMC1587832
- DOI: 10.1136/bmj.4.5889.382
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Use of 5-fluorocytosine in patients with impaired renal function
Br Med J.
.
Abstract
The plasma level and elimination of 5-fluorocytosine (5-FC) was measured in normal subjects and patients with impaired renal function. Prolongation of the half-life of the drug in renal failure has been confirmed. Renal clearance of 5-FC was about 75% of the creatinine clearance and a corresponding modification of drug dosage should be made in patients with renal insufficiency.
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