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. 1973 Nov 17;4(5889):382-4.
doi: 10.1136/bmj.4.5889.382.

Use of 5-fluorocytosine in patients with impaired renal function

J K Dawborn, M D Page, D J Schiavone

Use of 5-fluorocytosine in patients with impaired renal function

J K Dawborn et al. Br Med J. .

Abstract

The plasma level and elimination of 5-fluorocytosine (5-FC) was measured in normal subjects and patients with impaired renal function. Prolongation of the half-life of the drug in renal failure has been confirmed. Renal clearance of 5-FC was about 75% of the creatinine clearance and a corresponding modification of drug dosage should be made in patients with renal insufficiency.

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References

    1. Biochem Pharmacol. 1966 Apr;15(4):435-46 - PubMed
    1. Aust N Z J Med. 1972 May;2(2):153-8 - PubMed
    1. Br Med J. 1973 Nov 17;4(5889):380-2 - PubMed

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