[Equal sensitivity of normal or tumoral fibroblasts to cytotoxic and cytostatic effects of normal or "Corynebacterium parvum" activated peritoneal exudate cells (author's transl)]

Abstract

Cytotoxic and cytostatic properties of peritoneal exudate cells from BALB/c mice either normal or pretreated with Corynebacterium parvum normal were studied using as target cells two lines of BALB/c fibroblasts one normal (BALB) and one transformed by Kirsten virus (K.BALB).. C. parvum activated cells displayed higher cytotoxic as measured by 51Cr or 3H-thymidine release and cytostatic, as measured by 3H-thymidine incorporation, activities against these lines of syngeneic cells. Cytotoxic effect of normal peritoneal cells was evident when 51Cr or 3H-thymidine release was used whereas no such effect was found when cytolytic plaque formation test was used. Sensitivity of both BALB and K.BALB target cell lines was found to be equal to cytotoxic and cytostatic activities of C. parvum activated or normal syngeneic peritoneal cells.