Direct inhibition of gastric acid by growth-hormone release-inhibiting hormone in dogs

Abstract

To find out if growth-hormone release-inhibiting hormone (G.H.-R.I.H.) had any direct action on gastric acid production independent of its effect on gastrin release, cyclic G.H.-R.I.H. was infused at a rate of 20 mug. per kg. per hour into dogs with gastric fistulae. Gastric acid output fell sharply in response to three stimuli acid production--a meal and pentagastrin and histamine infusions. The fact that acid output was inhibited during pentagastrin administration suggests that G.H.-R.I.H. has a direct action on the gastric parietal cell.