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. 1979 Aug;40(2):253-9.
doi: 10.1038/bjc.1979.173.

Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen

P J Higgins, C Tong, E Borenfreund, R S Okin, A Bendich
Free PMC article

Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen

P J Higgins et al. Br J Cancer. 1979 Aug.
Free PMC article

Abstract

A late-gestation neonatal antigen (gamma foetal antigen; gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-FA from both foetus and tumour was obtained by molecular-sieve chromatography and sucrose-gradient centrifugation. Radial immunodiffusion analyses of organ extracts indicated that gamma-FA could be found in several neonatal tissues, the highest concentration occurring in the spleen. In the 2-month-old mouse, only splenic tissue contained gamma-FA and at much lower levels than in the organ of the newborn mouse.

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References

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