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. 1979 Aug 7;555(2):374-8.
doi: 10.1016/0005-2736(79)90179-2.

Sodium dependence of neutral amino acid uptake into rabbit ileum

M W Smith, F V Sepulveda

Sodium dependence of neutral amino acid uptake into rabbit ileum

M W Smith et al. Biochim Biophys Acta. .

Abstract

Alanine uses two mediated pathways to enter the rabbit ileal mucosa. Present results suggest that one of them (Km = 4.1 mM) is fully dependent on sodium in the mucosal medium, while the other (Km = 91 mM) is sodium-independent. Similar results are obtained for methionine and serine. Reinterpretation of previous alanine/sodium coupling coefficients suggests that two sodium ions per alanine molecule are transported via the high affinity system.

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