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Clinical Trial
. 1979 May;36(2):237-43.

Intravenous immunoglobulin therapy for antibody deficiency

M T Nolte, B Pirofsky, G A Gerritz, B Golding
Clinical Trial

Intravenous immunoglobulin therapy for antibody deficiency

M T Nolte et al. Clin Exp Immunol. 1979 May.

Abstract

Twenty patients with antibody deficiency were treated at random with either intramuscular immune serum globulin (ISG) or intravenous modified immune serum globulin (M-ISG). Fourteen patients received of 259 M-ISG infusions during 242 months of treatment. Catastrophic vasomotor reactions were not observed. A single dose of 150 mg/kilo M-ISG increased serum IgG values a mean 248 mg%. Intravenous M-ISG therapy was effective in reducing the incidence of acute infections. Subjects receiving M-ISG developed 0.103 acute infections per month of treatment. Patients injected with ISG had 0.295 acute infections per month of treatment. Seven subjects had separate courses of both intravenous M-ISG and intramuscular ISG. Acute infections per month of treatment for M-ISG and ISG were 0.104 and 0.406, respectively.

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